Gene Expression Literature Summary

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Kdr  kinase insert domain protein receptor   (Synonyms: Flk1, Flk-1, orv, vascular endothelial growth factor receptor- 2, VEGFR2, VEGFR-2, VEGF receptor-2)
Results	Reference
1	J:65909 Abbott BD, Buckalew AR, Placental defects in ARNT-knockout conceptus correlate with localized decreases in VEGF-R2, ang-1, and tie-2. Dev Dyn. 2000 Dec;219(4):526-38
1	J:202725 Borges L, Iacovino M, Koyano-Nakagawa N, Baik J, Garry DJ, Kyba M, Perlingeiro RC, Expression levels of endoglin distinctively identify hematopoietic and endothelial progeny at different stages of yolk sac hematopoiesis. Stem Cells. 2013 Sep;31(9):1893-901
1	J:32219 Carmeliet P, Ferreira V, Breier G, Pollefeyt S, Kieckens L, Gertsenstein M, Fahrig M, Vandenhoeck A, Harpal K, Eberhardt C, Declercq C, Pawling J, Moons L, Collen D, Risau W, Nagy A, Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele. Nature. 1996 Apr 4;380(6573):435-9
1	J:98373 Carvalho RL, Jonker L, Goumans MJ, Larsson J, Bouwman P, Karlsson S, Dijke PT, Arthur HM, Mummery CL, Defective paracrine signalling by TGFbeta in yolk sac vasculature of endoglin mutant mice: a paradigm for hereditary haemorrhagic telangiectasia. Development. 2004 Dec;131(24):6237-47
1	J:329888 Cioffi S, Flore G, Martucciello S, Bilio M, Turturo MG, Illingworth E, VEGFR3 modulates brain microvessel branching in a mouse model of 22q11.2 deletion syndrome. Life Sci Alliance. 2022 Dec;5(12):e202101308
1	J:303270 Collart C, Ciccarelli A, Ivanovitch K, Rosewell I, Kumar S, Kelly G, Edwards A, Smith JC, The migratory pathways of the cells that form the endocardium, dorsal aortae, and head vasculature in the mouse embryo. BMC Dev Biol. 2021 Mar 22;21(1):8
1*	J:177134 Cossette S, Misra R, The identification of different endothelial cell populations within the mouse proepicardium. Dev Dyn. 2011 Oct;240(10):2344-53
1	J:262042 Del Monte-Nieto G, Ramialison M, Adam AAS, Wu B, Aharonov A, D'Uva G, Bourke LM, Pitulescu ME, Chen H, de la Pompa JL, Shou W, Adams RH, Harten SK, Tzahor E, Zhou B, Harvey RP, Control of cardiac jelly dynamics by NOTCH1 and NRG1 defines the building plan for trabeculation. Nature. 2018 May;557(7705):439-445
1*	J:81327 Downs KM, McHugh J, Copp AJ, Shtivelman E, Multiple developmental roles of Ahnak are suggested by localization to sites of placentation and neural plate fusion in the mouse conceptus. Mech Dev. 2002 Dec;119 Suppl 1:S31-8
1	J:253732 Drummond CJ, Hanna JA, Garcia MR, Devine DJ, Heyrana AJ, Finkelstein D, Rehg JE, Hatley ME, Hedgehog Pathway Drives Fusion-Negative Rhabdomyosarcoma Initiated From Non-myogenic Endothelial Progenitors. Cancer Cell. 2018 Jan 8;33(1):108-124.e5
1	J:140543 Ema M, Yokomizo T, Wakamatsu A, Terunuma T, Yamamoto M, Takahashi S, Primitive erythropoiesis from mesodermal precursors expressing VE-cadherin, PECAM-1, Tie2, endoglin, and CD34 in the mouse embryo. Blood. 2006 Dec 15;108(13):4018-24
1	J:159118 Fotopoulou S, Oikonomou N, Grigorieva E, Nikitopoulou I, Paparountas T, Thanassopoulou A, Zhao Z, Xu Y, Kontoyiannis DL, Remboutsika E, Aidinis V, ATX expression and LPA signalling are vital for the development of the nervous system. Dev Biol. 2010 Mar 15;339(2):451-64
1	J:239361 Guimaraes-Camboa N, Stowe J, Aneas I, Sakabe N, Cattaneo P, Henderson L, Kilberg MS, Johnson RS, Chen J, McCulloch AD, Nobrega MA, Evans SM, Zambon AC, HIF1alpha Represses Cell Stress Pathways to Allow Proliferation of Hypoxic Fetal Cardiomyocytes. Dev Cell. 2015 Jun 08;33(5):507-21
1	J:224939 Hare LM, Schwarz Q, Wiszniak S, Gurung R, Montgomery KG, Mitchell CA, Phillips WA, Heterozygous expression of the oncogenic Pik3ca(H1047R) mutation during murine development results in fatal embryonic and extraembryonic defects. Dev Biol. 2015 Aug 1;404(1):14-26
1*	J:287156 Ishitobi H, Matsumoto K, Azami T, Itoh F, Itoh S, Takahashi S, Ema M, Flk1-GFP BAC Tg mice: an animal model for the study of blood vessel development. Exp Anim. 2010;59(5):615-22
1	J:205426 Jin Y, Liu Y, Lin Q, Li J, Druso JE, Antonyak MA, Meininger CJ, Zhang SL, Dostal DE, Guan JL, Cerione RA, Peng X, Deletion of Cdc42 enhances ADAM17-mediated vascular endothelial growth factor receptor 2 shedding and impairs vascular endothelial cell survival and vasculogenesis. Mol Cell Biol. 2013 Nov;33(21):4181-97
1	J:189368 Kamijo H, Matsumura Y, Thumkeo D, Koike S, Masu M, Shimizu Y, Ishizaki T, Narumiya S, Impaired vascular remodeling in the yolk sac of embryos deficient in ROCK-I and ROCK-II. Genes Cells. 2011 Oct;16(10):1012-21
1	J:214027 Kobayashi K, Ding G, Nishikawa S, Kataoka H, Role of Etv2-positive cells in the remodeling morphogenesis during vascular development. Genes Cells. 2013 Aug;18(8):704-21
1	J:63252 Kubo H, Fujiwara T, Jussila L, Hashi H, Ogawa M, Shimizu K, Awane M, Sakai Y, Takabayashi A, Alitalo K, Yamaoka Y, Nishikawa SI, Involvement of vascular endothelial growth factor receptor-3 in maintenance of integrity of endothelial cell lining during tumor angiogenesis. Blood. 2000 Jul 15;96(2):546-53
1	J:243177 Lania G, Ferrentino R, Baldini A, TBX1 Represses Vegfr2 Gene Expression and Enhances the Cardiac Fate of VEGFR2+ Cells. PLoS One. 2015;10(9):e0138525
1*	J:73279 Lechleider RJ, Ryan JL, Garrett L, Eng C, Deng Cx CX, Wynshaw-Boris A, Roberts AB, Targeted mutagenesis of smad1 reveals an essential role in chorioallantoic fusion. Dev Biol. 2001 Dec 1;240(1):157-67
1	J:179213 Li P, Pashmforoush M, Sucov HM, Mesodermal retinoic acid signaling regulates endothelial cell coalescence in caudal pharyngeal arch artery vasculogenesis. Dev Biol. 2012 Jan 1;361(1):116-24
1	J:99494 Li W, Ferkowicz MJ, Johnson SA, Shelley WC, Yoder MC, Endothelial cells in the early murine yolk sac give rise to CD41-expressing hematopoietic cells. Stem Cells Dev. 2005 Feb;14(1):44-54
1	J:212088 Mayeuf-Louchart A, Lagha M, Danckaert A, Rocancourt D, Relaix F, Vincent SD, Buckingham M, Notch regulation of myogenic versus endothelial fates of cells that migrate from the somite to the limb. Proc Natl Acad Sci U S A. 2014 Jun 17;111(24):8844-9
1	J:181007 Milgrom-Hoffman M, Harrelson Z, Ferrara N, Zelzer E, Evans SM, Tzahor E, The heart endocardium is derived from vascular endothelial progenitors. Development. 2011 Nov;138(21):4777-87
1*	J:123321 Nonaka H, Tanaka M, Suzuki K, Miyajima A, Development of murine hepatic sinusoidal endothelial cells characterized by the expression of hyaluronan receptors. Dev Dyn. 2007 Aug;236(8):2258-67
1	J:254695 Peng Y, Song L, Li D, Kesterson R, Wang J, Wang L, Rokosh G, Wu B, Wang Q, Jiao K, Sema6D acts downstream of bone morphogenetic protein signalling to promote atrioventricular cushion development in mice. Cardiovasc Res. 2016 Nov 1;112(2):532-542
1	J:276877 Qu X, Harmelink C, Baldwin HS, Tie2 regulates endocardial sprouting and myocardial trabeculation. JCI Insight. 2019 May 21;5
1	J:269217 Regano D, Visintin A, Clapero F, Bussolino F, Valdembri D, Maione F, Serini G, Giraudo E, Sema3F (Semaphorin 3F) Selectively Drives an Extraembryonic Proangiogenic Program. Arterioscler Thromb Vasc Biol. 2017 Sep;37(9):1710-1721
1	J:138069 Rolny C, Nilsson I, Magnusson P, Armulik A, Jakobsson L, Wentzel P, Lindblom P, Norlin J, Betsholtz C, Heuchel R, Welsh M, Claesson-Welsh L, Platelet-derived growth factor receptor-beta promotes early endothelial cell differentiation. Blood. 2006 Sep 15;108(6):1877-86
1*	J:104149 Siva K, Inamdar MS, Rudhira is a cytoplasmic WD40 protein expressed in mouse embryonic stem cells and during embryonic erythropoiesis. Gene Expr Patterns. 2006 Jan;6(2):225-34
1	J:186473 Somekawa S, Imagawa K, Hayashi H, Sakabe M, Ioka T, Sato GE, Inada K, Iwamoto T, Mori T, Uemura S, Nakagawa O, Saito Y, Tmem100, an ALK1 receptor signaling-dependent gene essential for arterial endothelium differentiation and vascular morphogenesis. Proc Natl Acad Sci U S A. 2012 Jul 24;109(30):12064-9
1*	J:166614 Stankunas K, Ma GK, Kuhnert FJ, Kuo CJ, Chang CP, VEGF signaling has distinct spatiotemporal roles during heart valve development. Dev Biol. 2010 Nov 15;347(2):325-36
1	J:142352 Stenman JM, Rajagopal J, Carroll TJ, Ishibashi M, McMahon J, McMahon AP, Canonical Wnt signaling regulates organ-specific assembly and differentiation of CNS vasculature. Science. 2008 Nov 21;322(5905):1247-50
1	J:156959 Sugiyama Y, Takabe Y, Nakakura T, Tanaka S, Koike T, Shiojiri N, Sinusoid development and morphogenesis may be stimulated by VEGF-Flk-1 signaling during fetal mouse liver development. Dev Dyn. 2010 Feb;239(2):386-97
1	J:51336 Takakura N, Huang XL, Naruse T, Hamaguchi I, Dumont DJ, Yancopoulos GD, Suda T, Critical role of the TIE2 endothelial cell receptor in the development of definitive hematopoiesis. Immunity. 1998 Nov;9(5):677-86
1	J:236405 Uchida K, Nakazawa M, Yamagishi C, Mikoshiba K, Yamagishi H, Type 1 and 3 inositol trisphosphate receptors are required for extra-embryonic vascular development. Dev Biol. 2016 Oct 1;418(1):89-97
1	J:238547 Wang X, Chen D, Chen K, Jubran A, Ramirez A, Astrof S, Endothelium in the pharyngeal arches 3, 4 and 6 is derived from the second heart field. Dev Biol. 2017 Jan 15;421(2):108-117
1	J:172232 Yang X, Gong Y, Friesel R, Spry1 is expressed in hemangioblasts and negatively regulates primitive hematopoiesis and endothelial cell function. PLoS One. 2011;6(4):e18374
1	J:231966 Zhang H, Pu W, Tian X, Huang X, He L, Liu Q, Li Y, Zhang L, He L, Liu K, Gillich A, Zhou B, Genetic lineage tracing identifies endocardial origin of liver vasculature. Nat Genet. 2016 May;48(5):537-43